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NSABP B-51± axillary radiation following neoadjuvant therapy

NSABP B-51 - A Randomized Phase III Clinical Trial Evaluating Post-Mastectomy Chestwall and Regional Nodal XRT and Post-Lumpectomy Regional Nodal XRT in Patients with Positive Axillary Nodes Before Neoadjuvant Chemotherapy Who Convert to Pathologically Negative Axillary Nodes After Neoadjuvant Chemotherapy

  • Clinical Trial Information

    Trial Contact: Manchola-Orozco, Carolina; Frankos, Marie

    Trial Phone: 321.841.7293 ; 321.841.7303

  • IRB No: B-51

    Protocol Abbrev: B-51

    Principal Investigator: Tomas Dvorak, MD

    Phase: Drug: Phase III

    Age Group: Adult

    Secondary Protocol No: NSABP B-51

    Treatment: Radiation: regional nodal Irradiation; Radiation: chestwall Irradiation; Radiation: Whole Brain Irradiation

    Therapies Involved: Radiation

    ClinicalTrials.gov ID: NCT01872975

  • Objective

    To evaluate whether the addition of chestwall+ regional nodal XRT after mastectomy or breast+ regional nodal XRT after breast-conserving surgery will significantly reduce the rates of recurrence in patients who have a complete response in the axillary nodes following neo-adjuvant therapy.

  • Key Eligibility

    Must have pathologically or histologically proven malignant axillary lymph nodes prior to neoadjuvant therapy.